稲田 利文(名古屋大学・大学院理学研究科・准教授)





Title of project

Diversity and asymmetry achieved by RNA program (RNA Regulation)

Head Investigator Name

Toshifumi Inada

Term of Project


Abstract of Research Project

The flow of genetic information from DNA via mRNA to Protein has been termed the central dogma of molecular biology. The gene regulations at the level of mRNA contribute to achieve diversity of cells and asymmetric cell division. The most important mechanism to increase the variation of gene products is alternative splicing, a way to produce different mature mRNAs from a primary transcript thereby producing different proteins from a single gene. Asymmetric localization of mRNA is a conserved mechanism to generate cellular diversity during development. Aberrant mRNAs could be produced by errors in these regulations, and mRNA surveillance systems recognize and eliminate aberrant mRNAs to guarantee the accuracy of gene expression. Recent researches have revealed that these regulations are interconnected. The aim of this research project is to understand molecular mechanism of these mRNA regulations, and discover novel factors involved in the regulation.


研究振興局 学術研究助成課

(研究振興局 学術研究助成課)

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